Sökning: "Margareta Wilhelm"

Hittade 2 avhandlingar innehållade orden Margareta Wilhelm.

1. 1. The p53-induced gene wig-1 : regulation of expression and role in embryonic development

   Författare :Margareta Wilhelm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The p53 tumor suppressor is a transcription factor that responds to various forms of cellular stress. Activated p53 induces growth arrest or apoptosis through transcriptional regulation of a wide range of target genes. More than 50% of human tumors carry mutations in the p53 gene, most of which reside within the DNAbinding core domain of p53. LÄS MER

3. 2. Utility of novel drug targets for treatment of metastatic cancer

   Författare :Tianyan Wang; Jenny Persson; Thomas Grundström; Maréne Landström; Margareta Wilhelm; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic cancer; castration-resistant prostate cancer; pancreatic ductal adenocarcinoma; target therapy; PIP5K1α; KRAS; molecularly imprinted polymers; Oncology; onkologi; molekylärbiologi; Molecular Biology; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. LÄS MER