Sökning: "Thomas Grundström"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Thomas Grundström.

  1. 1. Regulation of NF-κB by Calmodulin

    Författare :Åsa Antonsson; Thomas Grundström; Ylva Engström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; NF-κB; calmodulin; transcription; calcium; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Cells experience numerous external signals which they must respond to. Such signals arriving at the cell surface are transduced via various signal transduction pathways and often ultimately result in regulation of transcription. LÄS MER

  3. 2. Calmodulin mediated regulation of NF-kappaB in lymphocytes

    Författare :Sofia Edin; Thomas Grundström; Sam Okret; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium; CaM; CaMKII; NF-kappaB; Bc110; immunological synapse; Molecular biology; Molekylärbiologi;

    Sammanfattning : NF-κB transcription factors are regulators of a wide spectrum of genes involved in immune responses and inflammation as well as cellular proliferation and survival. Transcriptionally competent NF-κB dimers are retained in the cytoplasm of resting cells by binding to inhibitors of NF-κB (IκBs). LÄS MER

  4. 3. Regulation of B cell development by antigen receptors

    Författare :Jannek Hauser; Thomas Grundström; Yuan Zhuang; Umeå universitet; []
    Nyckelord :calcium; calmodulin; e-proteins; E2A; B cell development; antigen receptor signaling; surrogate light chains; RAG; allelic exclusion; V D J recombination; AID; negative feedback regulation; plasma cell differentiation;

    Sammanfattning : The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. LÄS MER

  5. 4. Regulation of activation of NF-κB by Calmodulin in T-lymphocytes

    Författare :Sreenivasa Rao Oruganti; Thomas Grundström; Eva Sverinson; Umeå universitet; []
    Nyckelord :Calcium; Calmodulin; CaMKII; TCR; Bcl10; NF-κB;

    Sammanfattning : Nuclear factor kappa B (NF-kB) is a widely expressed family of transcription factors that are involved in a diverse number of processes. These include inflammation or differentiation, survival or apoptosis, and proliferation or cell cycle arrest. LÄS MER

  7. 5. Calcium regulation and functions of basic Helix-Loop-Helix transcription factors

    Författare :Juha Saarikettu; Thomas Grundström; Dan Holmberg; Mikael Sigvardsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; calcium; calmodulin; calretinin; transcription; bHLH; E-protein; E2-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The members of the ubiquitously expressed E-protein subfamily of basic Helix-Loop-Helix (bHLH) transcription factors, E12/E47, SEF2-1 and HEB, have important roles as regulators of gene expression in various differentiation processes, including lymphocyte development and myogenesis. In myogenesis, E-proteins are proposed to function as obligate heterodimer partners for members of the MyoD family of muscle-specific bHLH transcription factors. LÄS MER