Sökning: "vesicular glutamate transporter 2"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden vesicular glutamate transporter 2.

1. 1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

   Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

   Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

3. 2. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

   Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

   Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

4. 3. Temporal dynamics of brain plasticity : characterizing brain structural changes during skill acquisition

   Författare :Tomás Mediavilla; Daniel Marcellino; Alexandra Badea; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motor learning; brain plasticity; structural plasticity; magnetic resonance imaging; voxel-based morphometry; tractography; connectivity; motor cortex; posterior parietal cortex; cerebellum; vesicular glutamate transporter;

   Sammanfattning : Traditionally, structural plasticity in the human brain has been considered to follow a linear or asymptotic increase over the course of training. However, recent studies using structural MRI revealed transient increases in grey matter volume (GMV) with learning. LÄS MER

5. 4. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

   Författare :Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

   Sammanfattning : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. LÄS MER

7. 5. Neocortical layer 2/3 microcircuits

   Författare :Carl Holmgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neocortical microcircuit; layer 2 3; pyramidal cell; FSN interneuron; retrograde signaling; VGLUT3; spike-timing dependent plasticity; LTP; LTD.;

   Sammanfattning : Pairs of interconnected neurons form elementary information processing units within neocortical microcircuits. Pyramidal cells within these microcircuits receive synaptic input, both from their connected partners, and from more distant cortical and sub-cortical regions. Consequently, they require a means to identify relevant synaptic signals. LÄS MER