Sökning: "SLRPs"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet SLRPs.

  1. 1. Studies on the extracellular matrix of the dysfunctional pelvic floor

    Författare :Marie Westergren Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pelvic floor; pelvic organ prolapse; stress urinary incontinence; extracellular matrix; collagen; SLRPs; decorin; lumican; fibromodulin; elastin associated proteins; fibrillin-1; fibulin-5; sex steroid hormone receptors; ER; PR; AR;

    Sammanfattning : Objective: Pelvic floor dysfunction cause impaired quality of life of many women and is one of the most common reasons for gynaecological surgery on benign indications. Little is known about the pelvic floor extracellular matrix as a pre-requisite for mechanical sustainability through vaginal delivery, age and hormonal changes. LÄS MER

  3. 2. Functions of small leucine-rich repeat proteoglycans in connective tissues

    Författare :Sebastian Kalamajski; Åke Oldbergs forskargrupp; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Biological properties of connective tissues rely heavily on collagen and its use in formation of extracellular networks (matrices) in which cells can live and move. To regulate the process of collagen matrix assembly, the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and influence its fibril formation. LÄS MER

  4. 3. Novel endogenous mechanisms of complement regulation - A delicate balance

    Författare :Andreas Holmér; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER

  5. 4. Extracellular matrix in atherosclerotic plaques: its role in plaque stability

    Författare :Christoffer Tengryd; Kardiovaskulär forskning - translationella studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix; Laminin; Collagen; Proteoglycans; Atherosclerosis; Carotid plaque; TGF-β;

    Sammanfattning : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. LÄS MER

  7. 5. Complement in Disease - Extracellular Proteins as Complement Regulators

    Författare :Kaisa Happonen; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER