Sökning: "PIB"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet PIB.

1. 1. Search for Biomarkers in ALS and Parkinson's Disease : Positron Emission Tomography and Cerebrospinal Fluid Studies

   Författare :Anders Johansson; Håkan Askmark; Lennart Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyotrophic lateral sclerosis; ALS; Parkinson’s disease; cerebrospinal fluid; positron emission tomography; vascular endothelial growth factor; fibroblast growth factor 2; proteomics; Fourier transform ion cyclotron resonance mass spectrometry; deprenyl-D2; PIB; FDG; L-[β11C]-DOPA; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : New biomarkers are needed to improve knowledge about pathophysiology, in order to provide earlier correct diagnosis and to follow disease progression of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The aim of this thesis was to find new biomarkers for these diseases. LÄS MER

3. 2. Biomarkers as Monitors of Drug Effect, Diagnostic Tools and Predictors of Deterioration Rate in Alzheimer’s Disease

   Författare :Malin Degerman Gunnarsson; Lena Kilander; Hans Basun; Jan Marcusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; biomarkers; CSF; PIB PET; amyloid-beta; tau; rapid cognitive decline; dying in severe dementia; mortality; neuropsychological tests; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Decreased amyloid-ß42 (Aß42), increased total tau (t-tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) reflect histopathological core changes in the most common dementia disorder, Alzheimer’s disease (AD). They discriminate AD from healthy controls and predict conversion to AD with a relatively high accuracy. LÄS MER

4. 3. Methodological aspects of quantitative cardiac molecular imaging

   Författare :Tanja Kero; Mark Lubberink; Håkan Ahlström; Elin Trägårdh; Uppsala universitet; []
   Nyckelord :PET; cardiac amyloidosis; 11C-PIB; retention index; standardized uptake value; PET-MR; MRI; myocardial blood flow; 15O-water; quantification; quantitative modeling;

   Sammanfattning : The objective of this research was to facilitate the use of quantitative cardiac molecular imaging by developing and validating methods and applications. More specifically:we determined the optimal tracer kinetic model for analysis of 11C-PIB and evaluated the performance of two simpler measures, retention index (RI) and standardized uptake value (SUV), in the quantification of cardiac 11C-PIB uptake in amyloidosis. LÄS MER

5. 4. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors

   Författare :Ahmadul Kadir; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer’s disease; cholinesterase inhibitors; positron emission tomography; nicotinic acetylcholine receptor; acetylcholinesterase; multi-tracer; 11C-nicotine; 11C-PMP; 18F-FDG; 11C-PIB; donepezil; rivastigmine; galantamine; phenserine.;

   Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. LÄS MER

7. 5. New regulators of xylem lignification in arabidopsis

   Författare :Bernadette Sztojka; Hannele Tuominen; Simon Hawkins; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Xylem; lignin; Arabidopsis; secondary cell wall; transcriptional regulation; lignin-biosynthetic gene; S G lignin ratio;

   Sammanfattning : The ability of land plants to grow upright, bear their own weight and withstand adverse environmental conditions is largely dependent on the secondary xylem tissues of the stem. The xylem cells acquire thick secondary cell walls which are composed of cellulose, hemicellulose and lignin. LÄS MER