Sökning: "multi-tracer"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet multi-tracer.

  1. 1. A multi-tracer PET approach to study early-onset familial and sporadic Alzheimer's disease

    Författare :Michael Schöll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cumulated scientific evidence suggests that the pathology causing Alzheimer's disease (AD) occurs many years or even decades before memory impairment and other clinical symptoms arise. Tangible and detailed knowledge about different pathological processes, their interactions, and time course is therefore of the essence both for the development of potentially successful treatments and a reliable early diagnosis of this relentless disorder. LÄS MER

  3. 2. Isotope Ratio and Trace Element Measurements Using Inductively Coupled Plasma – Mass Spectrometry : Method Development and Applications in Environmental Forensics

    Författare :Simon Pontér; Anders Widerlund; Hjalmar Laudon; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Isotope ratio measurements; screening analysis; ICP-MS; MC-ICP-MC; multi-tracer studies; fractionation; Environmental Forensics; Tracing; Tillämpad geokemi; Applied Geochemistry;

    Sammanfattning : Environmental Forensics is a scientific methodology developed for identifying sources, the timing of release, and transport pathways for potentially hazardous environmental contaminants. It combines a variety of analytical methods with principles derived from disciplines such as chemistry, geology, geochemistry, hydrogeology, and statistics, with the purpose to provide objective scientific and legal conclusions on the source and/or time of a contaminant release. LÄS MER

  4. 3. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors

    Författare :Ahmadul Kadir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer’s disease; cholinesterase inhibitors; positron emission tomography; nicotinic acetylcholine receptor; acetylcholinesterase; multi-tracer; 11C-nicotine; 11C-PMP; 18F-FDG; 11C-PIB; donepezil; rivastigmine; galantamine; phenserine.;

    Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. LÄS MER

  5. 4. Physics-informed inferences of galaxy clustering with Bayesian forward modelling

    Författare :Eleni Tsaprazi; Jens Jasche; Ariel Goobar; Alkistis Pourtsidou; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; large-scale structure; galaxy clustering; supernovae; Bayesian statistics; Physics; fysik;

    Sammanfattning : In this thesis, we showcase four novel approaches to constraining the relationship between cosmological observables and the large-scale structure. The majority of the energy content of the Universe in the concordance cosmological model remains largely unknown. LÄS MER

  7. 5. Isotope analysis of trace and ultra-trace elements in environmental matrices

    Författare :Nicola Pallavicini; Per Andersson; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Applied Geology; Tillämpad geologi;

    Sammanfattning : High precision isotope ratio measurements have found increasing application in various branches of science, from classical isotope geochronology to complex multi-tracer experiments in environmental studies. Progress in analytical technologies in recent years has allowed higher quality data to be obtained through mass spectrometry. LÄS MER