Sökning: "Liver injury"

Visar resultat 11 - 15 av 81 avhandlingar innehållade orden Liver injury.

  1. 11. Trauma - logistics and stress response

    Författare :Camilla Brorsson; Silvana Naredi; Anders Sylvan; Per Dahlqvist; Mikael Bodelsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; multiple trauma; hydrocortisone; adrenal insufficiency; hypnotics and sedatives; citric acid; glycerol; saliva; liver; colorectal surgery;

    Sammanfattning : Background: Trauma is a major cause of death and disability. Adverse events, such as prolonged prehospital time, hypoxia, hypotension and/or hyperventilation have been reported to correlate to poor outcome.Adequate cortisol levels are essential for survival after major trauma. LÄS MER

  3. 12. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

    Författare :Jenny M. Pedersen; Per Artursson; Christel A. S. Bergström; Stefan Oswald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER

  4. 13. Hepatic ischemia-reperfusion injury

    Författare :Melroy Alistair D'Souza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hepatic ischemia-reperfusion (I/R) injury is a complex phenomenon occuring in response to interruption of the liver’s blood and oxygen supply and the subsequent restoration of blood flow and tissue oxygenation. Techniques to reduce blood loss and other intra-operative manoeuvers during liver resection can cause hepatic I/R injury. LÄS MER

  5. 14. Liver transplantation in man. Gastrointestinal perfusion and inflammatory response

    Författare :Ebbe Rønholm; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; carbondioxide; complement activation; cytokines; endotoxaemia; hydrogen-ion concentration; liver transplantation; laser-Doppler flowmetry; PMN elastase; regional blood flow; reperfusion;

    Sammanfattning : Patients undergoing liver transplantation develop a systemic inflammatory response which eventually continues with development of a multiple organ dysfunction syndrome (MODS). Gastro-intestinal hypoxia or bacterial translocation has been proposed as the "motor" of MODS. LÄS MER

  7. 15. New techniques in liver surgery

    Författare :Ulf Jersenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The development of liver surgery has a long history and through the years, much knowledge has been gathered concerning various aspects of the liver. The exploration and understanding of liver anatomy and liver regeneration and development of surgical techniques are important landmarks. LÄS MER