Sökning: "Fab fragments"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Fab fragments.

  1. 1. Polyelectrolytes and Polycomplexes in Biotechnology

    Författare :Maria Dainiak; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; expanded bed adsorption.; affinity precipitation; Fab fragments; monoclonal antibodies; glyceraldehyde-3-phosphate dehydrogenase; misfolded protein; chaperone; poly N-ethyl-4-vinylpyridinium bromide ; poly methacrylic acid ; poly acrylic acid ; Key words: polyelectrolyte; polyelectrolyte complexes; Biotechnology; Bioteknik; Chemical technology and engineering; Kemiteknik och kemisk teknologi;

    Sammanfattning : Polyelectrolytes and polyelectrolyte complexes (PECs) are characterized by many useful properties that endow them with high potential in different areas of biotechnology. This thesis describes the development and analyses of some new systems and methods utilizing poly(acrylic acid) (PAA), poly(methacrylic acid) (PMA), poly (N-ethyl-4-vinylpyridinium bromide) (PEVP) and PMA-PEVP complexes. LÄS MER

  3. 2. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Författare :Anna-Karin Haylock; Marika Nestor; Göran Laurell; Matti Anniko; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. LÄS MER

  4. 3. Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

    Författare :Laila Sakhnini; Tillämpad biokemi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents;

    Sammanfattning : Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. LÄS MER

  5. 4. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Författare :Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Sammanfattning : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. LÄS MER

  7. 5. Puumala hantavirus : immune responses and vaccines

    Författare :Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

    Sammanfattning : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. LÄS MER