Sökning: "neutralising antibodies"
Visar resultat 1 - 5 av 29 avhandlingar innehållade orden neutralising antibodies.
1. Glycoprotein B of human cytomegalovirus : target for neutralising antibodies, ligand for cellular receptors, inducer of autoimmunity?
Sammanfattning : Human cytomegalovirus (HCMV), a member of the Herpesviridae, is widespread in humans, causing persistent infections mostly without any clinical symptoms. However in immunosuppressed individuals HCMV still represents a significant factor in morbidity, why there is clearly a need for effective therapy and prophylaxis against HCMV infection. LÄS MER
2. Haemophilia B - Diagnostic Insights, Genetic Aspects and Clinical Outcomes
Sammanfattning : Haemophilia B (HB) is a rare inherited bleeding disorder caused by the deficiency of coagulation factor IX (FIX). The major clinical issues are bleedings, often targeting the joints, and the development of neutralising antibodies, i.e. inhibitors, to the FIX replacement therapy. LÄS MER
3. Monoclonal antibodies and cytokines for therapy of patients with advanced colorectal carcinoma : a clinical and immunological study
Sammanfattning : There is a great need for developing and improving treatment alternatives in colorectal carcinoma (CRC). The tumour associated antigen (TAA) GA733/CO17-1A is expressed by more than 90% of all CRCs, on the majority of both primary and metastatic CRC cells. LÄS MER
4. HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses
Sammanfattning : This thesis describes the evaluation of HIV vaccines candidates in the HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of the vaccines were investigated. Furthermore, correlates to protective immunity were sought. LÄS MER
5. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism
Sammanfattning : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. LÄS MER