Sökning: "Drug partitioning"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Drug partitioning.
1. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure
Sammanfattning : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. LÄS MER
2. Drug Partitioning into Natural and Artificial Membranes : Data Applicable in Predictions of Drug Absorption
Sammanfattning : When drug molecules are passively absorbed through the cell membrane in the small intestine, the first key step is partitioning of the drug into the membrane. Partition data can therefore be used to predict drug absorption. LÄS MER
3. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes
Sammanfattning : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. LÄS MER
4. Nanosized Bilayer Disks as Model Membranes for Interaction Studies
Sammanfattning : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. LÄS MER
5. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers
Sammanfattning : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. LÄS MER