Sökning: "vaccine trial"

Visar resultat 21 - 25 av 39 avhandlingar innehållade orden vaccine trial.

  1. 21. Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia

    Författare :Parviz Kokhaei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immunotherapy; dendritic cells. chronic lymphocytic leukemia; tumor vaccine; T lymphocyte;

    Sammanfattning : A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for loading antigen on dendritic cells (DC) with the aim of delineating the most effective antigen presentation platform for stimulating anti-leukemic T cells. LÄS MER

  3. 22. Variable viral genes as genetic immunogens

    Författare :Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

    Sammanfattning : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. LÄS MER

  4. 23. Novel vaccines and antiviral treatments for enterovirus induced infections and disease

    Författare :Marta Butrym; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Enterovirus infections are common around the world and can impact people’s lives in various ways, causing pancreatitis, myocarditis, common cold and more. This thesis is focused on testing the effectiveness of new vaccines and an antiviral agent in the context of cystic fibrosis (CF) and type 1 diabetes (T1D). LÄS MER

  5. 24. Prime-boost immunization strategies against HIV-1

    Författare :Andreas Bråve; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Since the start of the global HIV epidemic in 1981, more than twentyfive million people have succumbed to AIDS-related diseases. The epidemic is most severe in Sub-Saharan Africa, where twentyfive million people are currently infected and more than two million died during 2006. LÄS MER

  7. 25. B-cell responses after pertussis vaccination

    Författare :Maja Jahnmatz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite years of vaccination efforts, whooping cough, or pertussis, is not under control. Although immunization has greatly reduced the disease incidence, thousands of children die of whooping cough each year. LÄS MER