Sökning: "teratogenicity"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet teratogenicity.

1. 6. Teratogenicity Involved in Experimental Diabetic Pregnancy

   Författare :Mattias Gäreskog; Parri Wentzel; Ulf Eriksson; Jonas Cederberg; Kari Teramo; Uppsala universitet; []
   Nyckelord :Cell biology; Diabetes; Pregnancy; PKC; Apoptosis; Rat; Embryopathy; Vitamin E; Folic acid; CHC; NAC; Cellbiologi;

   Sammanfattning : Maternal diabetes is associated with increased risk of growth disturbances and congenital malformations. The malformations rate in the offspring of diabetic mothers is 2-3 fold higher compared to infants of nondiabetic mothers. LÄS MER

3. 7. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

   Författare :Faranak Azarbayjani; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

   Sammanfattning : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. LÄS MER

4. 8. Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart

   Författare :Christian Danielsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. LÄS MER

5. 9. Teratogenicity and in vitro fetal thymus toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners : segregation with the Ah-locus

   Författare :Ezdihar Abdul-Malek Hassoun; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Sammanfattning : .... LÄS MER

7. 10. Assessment of Drug-Induced Cardiotoxicity during Rat Embryo Development

   Författare :Mats Nilsson; William S. Webster; Nigel A. Brown; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The potassium ion channel (hERG/IKr) is important for normal heart function and drug-induced blockade of the channel in adult humans can lead to irregular heart rhythms (arrhythmia).  The ion channel is also essential for early cardiac function in the embryo and therapeutic drugs which block this channel have been shown to cause birth defects in animal studies. LÄS MER