Sökning: "single-stranded oligonucleotides"

Visar resultat 21 - 22 av 22 avhandlingar innehållade orden single-stranded oligonucleotides.

1. 21. Exploring the transcriptional space

   Författare :Joseph Bergenstråhle; Joakim Lundeberg; Jay W. Shin; KTH; []
   Nyckelord :Transcriptomics Spatial; Bioteknologi; Biotechnology;

   Sammanfattning : Transcriptomics promises biological insight into gene regulation, cell diversity, and mechanistic understanding of dysfunction. Driven by technological advancements in sequencing technologies, the field has witnessed an exponential growth in data output. Not only has the amount of raw data increased tremendously but it’s granularity as well. LÄS MER

3. 22. Optimization of the formulation and design of oligonucleotide-based pharmaceuticals for the purpose of gene therapy

   Författare :Eman M Zaghloul; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. LÄS MER