Sökning: "primary HIV- I infection"

Visar resultat 16 - 20 av 43 avhandlingar innehållade orden primary HIV- I infection.

1. 16. Studies of drug resistance in minor HIV quasispecies

   Författare :Halime Ekici; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The main objective was to study drug resistance mutations (DRM) in the HIV-1 reverse transcriptase (RT) gene of minor HIV-1 quasispecies, not detectable with standard techniques. Sensitive allele-specific PCR (AS- PCR) and next-generation sequencing (NGS) were developed to study resistance to drugs of relevance in low- and middle-income countries (LMIC); the nucleoside analogue RT inhibitor (NRTI) lamivudine (3TC) and the non-nucleoside RT inhibitors (NNRTIs) efavirenz (EFV) and nevirapine (NVP). LÄS MER

3. 17. Dendritic cell and IgA responses in SIV and HIV-1 pathogenesis

   Författare :Johan Söderlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DC; SIV; HIV-1; macaques; neutralizing antibodies; IgA;

   Sammanfattning : Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV-1) can infect different subsets of dendritic cells (DC). Such cells may therefore not only be involved in the generation of recruitment of naïve T and B lymphocytes in induction of SIV/HIV-1 specific adaptive responses but also transmit virus from port of entrance to the secondary lymphoid compartment generating systemic viral spread. LÄS MER

4. 18. Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection

   Författare :Rebecka Lantto Graham; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Microbial translocation and increased immune activation have been involved in functional T cell impairments and disease progression during HIV-1 infection. The impact of microbial translocation on the phenotype of memory B cells in HIV-1 infected patients was studied in paper I. LÄS MER

5. 19. Mucosal immune responses in HIV-1 exposed uninfected individuals

   Författare :Taha Hirbod; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The development of HIV vaccines and immunotherapeutics remains hampered by our lack of understanding correlates of immune protection to infection and disease. The major (perhaps only) piece of evidence indicating that long-term, solid resistance to HIV infection is indeed possible comes from HIV exposed yet uninfected individuals (EUI). LÄS MER

7. 20. Optimization of TB/HIV co-treatment in Ethiopian patients

   Författare :Wondwossen Amogne Degu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tuberculosis (TB) and HIV infection act with deadly synergy. HIV is the most important risk factor for latent TB reactivation and active TB progression following exposure or reinfection while TB accelerates HIV progression. TB is the most frequent cause of morbidity and mortality in HIV infection. LÄS MER