Sökning: "macaques"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet macaques.

1. 1. HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses

   Författare :Charlotta Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Vaccines; HIV-2; SIV; macaques; adjuvant; immune response; antibodies; neutralising antibodies; cell-mediated immunity; T-cell proliferation; CTL;

   Sammanfattning : This thesis describes the evaluation of HIV vaccines candidates in the HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of the vaccines were investigated. Furthermore, correlates to protective immunity were sought. LÄS MER

3. 2. Dendritic cell and IgA responses in SIV and HIV-1 pathogenesis

   Författare :Johan Söderlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DC; SIV; HIV-1; macaques; neutralizing antibodies; IgA;

   Sammanfattning : Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV-1) can infect different subsets of dendritic cells (DC). Such cells may therefore not only be involved in the generation of recruitment of naïve T and B lymphocytes in induction of SIV/HIV-1 specific adaptive responses but also transmit virus from port of entrance to the secondary lymphoid compartment generating systemic viral spread. LÄS MER

4. 3. Testosterone and the postmenopausal breast : aspects on cell proliferation and mammographic density

   Författare :Marie Hofling; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Menopause; testosterone; breast cell proliferation; fine needle aspiration biopsy; mammographic density; Syndecan-1; androgen receptor; cynomolgus macaques;

   Sammanfattning : The breast is a target organ for sex steroids, and hormonal treatments have been associated with a risk of breast cancer. There is increasing interest in androgen treatment for postmenopausal women. Testosterone has been shown to improve bone density, body composition, mood, psychosexual function and general well-being. LÄS MER

5. 4. Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation

   Författare :Erika Isaksson Friman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Oral contraceptives; hormone replacement therapy; breast epithelial proliferation; cynomolgus macaques; ER-alpha and ER-beta; PRA and PRB; tamoxifen; IGF-I; p53.;

   Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Hormonal treatments for contraception and replacement after menopause have been associated with an increased risk of breast cancer. The basis of risk associated with hormonal therapies may lie in the regulation of cell proliferation. LÄS MER

7. 5. Hormone therapy and the breast : aspects on proliferation, apoptosis and mammographic density

   Författare :Peter Conner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast cell proliferation; fine needle aspiration cytology; menopause; hormone replacement therapy; tibolone; mammographic breast density; continuous combined hormone therapy; p53; apoptosis; cynomolgus macaques.;

   Sammanfattning : Breast cancer is the major malignancy among women in the western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. Still, basic knowledge as to how sex steroids influence the normal breast is remarkably poor. LÄS MER