Sökning: "p -condition"

Visar resultat 36 - 40 av 9476 avhandlingar innehållade orden p -condition.

  1. 36. Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo

    Författare :Kajsa P Kanebratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 (P450) enzymes comprise the most important enzyme system with regard to phase I metabolism of drugs. Induction of P450s can result in decreased plasma concentrations of the drug itself or a coadminstered drug, followed by lack of effect. LÄS MER

  3. 37. Modulation of cellular and viral functions in Epstein-Barr virus infected cells

    Författare :Marta P Imreh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the study was to investigate the interplay of cellular and viral genes in Epstein-Barr virus (EBV) infected cells. Two aspects of this interaction have been investigated. The first aspect is related to the expression of major histocompatibility complex (MHC) class I molecules in virus infected malignant cells. LÄS MER

  4. 38. Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions

    Författare :Jovan P Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thrombin activatable fibrinolysis inhibitor TAFI ; coagulation; fibrinolysis; thrombin; plasmin; factor V Leiden; hemophilia; von Willebrand disease; diabetes mellitus; preeclampsia;

    Sammanfattning : Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis. LÄS MER

  5. 39. Nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants in breast cancer

    Författare :Kristinn P Benediktsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: The surgical treatment of breast cancer has changed rapidly since Halsted´s operation was generally abandoned about 50 years ago. In the 1970s partial mastectomy (PM), followed by radiotherapy (RT), was proven to be oncologically safe for smaller cancer tumours that are not multifocal. LÄS MER

  7. 40. Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG

    Författare :Jonas P Bergström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alcohol use and abuse is a major social and economic problem in many societies. Carbohydrate-deficient transferrin (CDT) is a widely used and highly specific biochemical alcohol marker of prolonged alcohol abuse. LÄS MER