Sökning: "class Ic"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden class Ic.

  1. 1. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases

    Författare :Ana Popović-Bijelić; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; class Ic; C. trachomatis; cytotoxicity; KP772; lanthanum; manganese–iron cofactor; metal complex; oligopeptide inhibitor; ribonucleotide reductase; Triapine; tyrosyl radical; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. LÄS MER

  2. 2. Globulettes : a new class of very small and dense interstellar clouds

    Författare :Tiia Grenman; Luleå tekniska universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Fysik; Fysik;

    Sammanfattning : The space between stars is not empty, but filled with a thin gas and microscopic dust grains, together forming the so-called interstellar medium. Matter is concentrated into clouds of very different sizes, ranging from giant molecular cloud complexes to massive isolated dark small isolated cloudlets, called globules. LÄS MER

  3. 3. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms

    Författare :Maria Öhrström; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. LÄS MER

  4. 4. CMOS RF Power Amplifiers for Wireless Communications

    Författare :Jonas Fritzin; Atila Alvandpour; Henrik Sjöland; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : The wireless market has experienced a remarkable development and growth since the introduction of the first modern mobile phone systems, with a steady increase in the number of subscribers, new application areas, and higher data rates. As mobile phones and wireless connectivity have become consumer mass markets, the prime goal of the IC manufacturers is to provide low-cost solutions. LÄS MER

  5. 5. Manganese and Iron Heterodimers and Homodimers in Enzymes : Insights from Density Functional Theory

    Författare :Katarina Roos; Per Siegbahn; Margareta R. A. Blomberg; Frank Neese; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Ribonucleotide reductase; manganese; iron; density functional theory; kemisk fysik; Chemical Physics;

    Sammanfattning : The enzyme ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to deoxyribonucleotides, the building blocks of DNA, and is essential for all organisms. Canonical class I RNR R2 proteins use a diiron cofactor to generate a tyrosyl radical, which is required for catalysis. LÄS MER