Sökning: "nephron number"

Hittade 4 avhandlingar innehållade orden nephron number.

  1. 1. The developing rat kidney : the dopamine system and related serine/threonine kinases and phosphatases

    Författare :Johan Svennilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; confocal immunofluorescence; DARPP-32; dopamine; foetal renal development; hypertension; in situ hybridization; metanephric culture; mouse; nephron number; PKC; PP1 PP2A; protein phosphorylation; rat;

    Sammanfattning : The kidney originates from the fusion and conversion of two tissues: the metanephric mesenchyme and the ureter epithelium, an evagination from the Wolffian duct. Although a number of candidate molecules have been shown to be of importance for the differentiation of the embryonic kidney, many of the signalling pathway leading to this development are still obscure. LÄS MER

  3. 2. Renal Klotho in mineral metabolism

    Författare :Risul Amin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcium and phosphorous are critical elements in a number of physiological processes, including maintenance of bone structure, cell signaling and energy metabolism. Their endocrine regulation is tightly controlled through a number of feedback mechanisms involving parathyroid hormone (PTH), vitamin D and the recently discovered fibroblast growth factor 23 (FGF23). LÄS MER

  4. 3. Genetic predisposition to salt sensitivity and cardiovascular disease

    Författare :Jonas Dahlberg; Kardiovaskulär forskning - hypertoni; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NEDD4L; SGK-1; CVD; ischemic stroke; genetics; CVD deaths; myopcardial infarction;

    Sammanfattning : Abstract The average amount of salt ingested is about 10 grams daily compared to less than one gram in pre-historic life. Salt, althought somewhat debated, is considered a risk factor for elevated blood pressure and end organ damage beyond the blood pressure effect. LÄS MER

  5. 4. Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation

    Författare :Olga Beltcheva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nephrin; NPHS 1; CNF; podocytes; promoter;

    Sammanfattning : Kidneys, the main excretory organs in vertebrates, play central role in removing water soluble metabolic waste products from the organism. Many acquired and inherited renal diseases in man lead to kidney dysfunction and nephrotic syndrome - life-threatening condition affecting increasing number of people in the modem society. LÄS MER