Sökning: "inhibitor tolerance"

Visar resultat 16 - 20 av 53 avhandlingar innehållade orden inhibitor tolerance.

1. 16. Optimizing nicotinic acid delivery for durable antilipolysis and improved metabolic control

   Författare :Tobias Kroon; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Type 2 diabetes is a devastating disease affecting hundreds of millions worldwide. Lipid accumulation in peripheral non-adipose tissues is a major driver of insulin resistance, a central pathophysiological defect of this disease. LÄS MER

3. 17. Fermentation Inhibitors in the Production of Bio-ethanol: Detoxification of Lignocellulose Hydrolyzates and Physiological Effects of Furfural on Yeast

   Författare :Ilona Sárvári Horváth; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; detoxification; fermentation inhibitors; metabolic flux analysis; Saccharomyces cerevisiae; lignocellulose; ethanol; chemostat; furfural conversion;

   Sammanfattning : Different strategies to overcome inhibitor problems in the production of bio-ethanol from lignocellulose hydrolyzates with the yeast Saccharomyces cerevisiae were examined. The strategies included detoxification prior to fermentation and in situ detoxification of furfural. A strain development for improved inhibitor tolerance was also initiated. LÄS MER

4. 18. Clinical studies in severe heart failure : neurohormonal, electrolyte and metabolic aspects

   Författare :Mats Broqvist; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Congestive heart failure is a common and complex syndrome with a poor prognosis. Although heart disease is usually the primary event, the clinical syndrome is characterised by several extra-cardiac manifestations. Neurohormonal activation seems to play a crucial role for these manifestations and the progression of the disease. LÄS MER

5. 19. DNA Analysis of PCR-Inhibitory Forensic Samples

   Författare :Johannes Hedman; Teknisk mikrobiologi; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; amylase; statistical modelling; principal components analysis; PCR inhibitors; PCR inhibition; forensic DNA analysis; DNA polymerase blend; DNA polymerase; crime scene samples;

   Sammanfattning : DNA evidence, linking perpetrators to crime scenes, is central to many legal proceedings. However, crime scene samples often contain extraneous substances that may interfere with the PCR-based forensic analysis, resulting in partial or negative DNA profiles. Extensive DNA purification may remove inhibitors, but involves the risk of DNA loss. LÄS MER

7. 20. IDO gene expression induction by DNA methylation inhibitors

   Författare :Hua Liu; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The aim was to study the effect of DNA methylation of CpG motifs in cancer cells and immune cells by use of the DNA methyltransferas (DNMT) inhibitor zebularine. In cancer cells it is known that genes can be silenced by chromosomal deletion(s). It is also known that genes can be silenced by DNA methylation or expression of micro-RNA. LÄS MER