Sökning: "iPLA 2"

Hittade 2 avhandlingar innehållade orden iPLA 2.

1. 1. Biosynthesis of leukotriene B4 in hematological malignancies

   Författare :Gudmundur Runarsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :LTB 4; 5-LO; cPLA 2; iPLA 2; AML; B-ALL; B-CLL;

   Sammanfattning : Leukotrienes (LT) are biologically active metabolites of the fatty acid arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA 2), this fatty acid can be converted to leukotrienes, lipoxins, prostaglandins or thromboxane. The conversion of AA to LTA 4 is catalyzed by five-lipoxygenase (5-LO). LÄS MER

3. 2. The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies

   Författare :Jane M. Hayden; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Local anaesthetics; postoperative pain; hysterectomy; inflammation; ropivacaine toxicity; ovarian cancer; recovery; ovarian cancer cells;

   Sammanfattning : Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of LAs on cancer cells when administered in therapeutic concentrations. LÄS MER