Sökning: "dendritic ligands"

Visar resultat 6 - 10 av 37 avhandlingar innehållade orden dendritic ligands.

  1. 6. Therapeutic dendritic cell vaccination against human papillomavirus

    Författare :Merja Nurkkala Karlsson; Göteborgs universitet; []
    Nyckelord :human papillomavirus; therapeutic dendritic cell vaccination; cholera toxin; T cells; TLRs and CpG;

    Sammanfattning : Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually. The two currently available HPV vaccines can only be used prophylactically, so they are of no use to the 291 million women who are already infected and at risk of developing cancer. LÄS MER

  3. 7. Strategies for modulation of dendritic cell responses

    Författare :Annette E Sköld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With increased knowledge in dendritic cell (DC) biology, innate immune receptors and their ligands, and the shaping of adaptive responses, refined approaches to modulate our immune system are today emerging as treatment strategies for chronic infections and severe cancers. At the center of attention stand DCs – the innate immune cells that orchestrate the adaptive immune responses. LÄS MER

  4. 8. Regulation of dendritic cell differentiation, maturation and activation

    Författare :Jin Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immune system efficiently protects the host from exogenous pathogens such as bacteria, virus and parasites and endogenous threats such as damaged cells and tumors. Invasion of pathogens and other threats activate the innate immunity causing secretion of pro-inflammatory cytokines with the subsequent antigen presentation and activation of the adaptive immunity resulting in T and B cell responses. LÄS MER

  5. 9. Processing and presentation of exogenous antigen by dendritic cells

    Författare :Liying Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DC; vesicular MHC-I processing; Adenosine; CD 1 d; TACA;

    Sammanfattning : Dendritic cells (DC) play a key role in the immune system. In this thesis, we have investigated and characterized pathways for the processing and presentation of exogenous OVA on MHC-I ("cross-presentation") and how these were influenced by the purine nucleoside Adenosine (Ado), an immune regulator that accumulates to high concentrations at sites of inflammation and tumor growth. LÄS MER

  7. 10. Toll-like receptor activation induced changes in dendritic cells

    Författare :Oscar Hammarfjord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dendritic cells (DC) are professional antigen-presenting cells that act as a “bridge” between innate and adaptive immunity by the induction and subsequent orchestration of immune responses. The ligation of Toll-like receptors (TLR) and other innate receptors on DC determines their immune-stimulating capacity. LÄS MER