Sökning: "antibody validation"
Visar resultat 31 - 34 av 34 avhandlingar innehållade orden antibody validation.
31. Discovering circulating protein biomarkers through in-depth plasma proteomics
Sammanfattning : Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. LÄS MER
32. Role of cholesterol metabolism in hepatic steatosis and glucose tolerance
Sammanfattning : The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular diseases (ASCVD), type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD).The overall aim of this thesis was to expand the knowledge on how genetic and pharmacological interventions on hepatic and intestinal cholesterol metabolism could affect the pathophysiology of CMD. LÄS MER
33. Acute myeloid leukemia : apoptotic signalling and gene expression associated with treatment response
Sammanfattning : Acute myeloid leukemia (AML) is a severe, life threatening malignancy characterized by a clonal expansion of immature myeloid cells in the bone marrow, resulting in severe infections and bleedings. High dose chemotherapy is able to normalize the blood and bone marrow morphology (complete remission, CR) in a majority of treated patients, but recurrent disease, typically occurs within 1-2 years. LÄS MER
34. Aminoacyl tRNA synthetases and their connection to autoimmune rheumatic disease
Sammanfattning : Idiopathic inflammatory myopathies (IIM, collectively called myositis) are rare autoimmune rheumatic diseases characterized by chronic inflammation and associated with high mortality and morbidity (1, 2). The disease nomenclature tells us that IIM has traditionally been described as a group of diseases mainly affecting the skeletal muscle, with muscle weakness and weakened muscle endurance as the dominating clinical symptoms (3). LÄS MER
