Sökning: "Subcellular pathway models"

Hittade 3 avhandlingar innehållade orden Subcellular pathway models.

  1. 1. Markov Chain Monte Carlo Methods and Applications in Neuroscience

    Författare :Federica Milinanni; Pierre Nyquist; Mark Clements; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Markov chain Monte Carlo; Large deviations; Subcellular pathway models; Markov chain Monte Carlo; Stora avvikelser; Subcellular pathway models; Tillämpad matematik och beräkningsmatematik; Applied and Computational Mathematics;

    Sammanfattning : An important task in brain modeling is that of estimating model parameters and quantifying their uncertainty. In this thesis we tackle this problem from a Bayesian perspective: we use experimental data to update the prior information about model parameters, in order to obtain their posterior distribution. LÄS MER

  3. 2. The expression of the structural proteins dendrin, Plekhh2 and Neph1 in the glomerular filtration barrier

    Författare :Jenny Hulkko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The podocytes are injured in many acquired glomerular diseases. This may present as proteinuria or morphological changes such as foot process effacement (FPE) or loss of podocytes in the urine. The exact mechanisms are still mainly unknown. LÄS MER

  4. 3. Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking

    Författare :Saket Milind Nigam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit atrophy, but the underlying mechanisms for neurodegeneration continues to be point of debate. LÄS MER