Sökning: "IDH mutation."

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden IDH mutation..

  1. 1. Deep Learning Methods for Classification of Glioma and its Molecular Subtypes

    Författare :Muhaddisa Barat Ali; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; 1p 19q codeletion; generative adversarial network; convolutional neural network; glioma subtype classification; IDH mutation.; Deep learning; cycleGAN; convolutional autoencoder;

    Sammanfattning : Diagnosis and timely treatment play an important role in preventing brain tumor growth. Clinicians are unable to reliably predict LGG molecular subtypes from magnetic resonance imaging (MRI) without taking biopsy. Accurate diagnosis prior to surgery would be important. LÄS MER

  3. 2. Deep Learning Methods for Classification of Gliomas and Their Molecular Subtypes, From Central Learning to Federated Learning

    Författare :Muhaddisa Barat Ali; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; glioma subtype classification; convolutional autoencoder; convolutional NN; multi-stream U-Net.; CycleGAN; 1p 19q codeletion; federated learning; IDH mutation; generative adversarial network; Deep learning;

    Sammanfattning : The most common type of brain cancer in adults are gliomas. Under the updated 2016 World Health Organization (WHO) tumor classification in central nervous system (CNS), identification of molecular subtypes of gliomas is important. LÄS MER

  4. 3. On the Surgical Management of Diffuse Low-Grade Gliomas in Adults

    Författare :Louise Carstam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diffuse Low-Grade Gliomas; Surgery; IDH-mutation;

    Sammanfattning : Diffuse low-grade gliomas (dLGG) are rare, slow-growing, yet difficult-to-treat brain tumors that typically affect young to middle-aged adults. The aim of the thesis has been to identify factors affecting management and outcome in terms of symptoms and primarily survival for patients with dLGG. LÄS MER

  5. 4. Improving NK cell-based immunotherapy of cancer by exploration of migration and inhibitory receptor-ligand interactions

    Författare :Filip Segerberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The possibility to utilize the immune system as a mean to target malignantly transformed cells has emerged as a novel treatment modality during the last decades and is a field that is under rapid development. Natural Killer (NK) cells are immune cells with an intrinsic ability to recognize and lyse tumor-transformed cells. LÄS MER

  7. 5. Aberrant DNA methylation in acute myeloid leukemia

    Författare :Ying Qu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). LÄS MER