Sökning: "GK"

Visar resultat 11 - 15 av 57 avhandlingar innehållade ordet GK.

  1. 11. Functional and genetic studies in type 2 diabetes and obesity

    Författare :Mohammed Hamza Z E Seed Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and mortality. LÄS MER

  3. 12. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

  4. 13. Studies on factors modulating glucose homeostasis in healthy and diabetic rats

    Författare :Kamal Yassin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :glucose homeostasis;

    Sammanfattning : Glucose is the most common substrate for energy metabolism. Despite the varying demands for glucose, the body needs to regulate its internal environment and maintain a constant and stable condition. Glucose homeostasis requires harmonized interaction between several tissues, achieving equilibrium between glucose output and uptake. LÄS MER

  5. 14. Genetic dissection of multifactorial disease models in the rat

    Författare :Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

    Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER

  7. 15. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model

    Författare :Ezarul Faradianna Lokman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes;

    Sammanfattning : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. LÄS MER