Sökning: "VAMP-2."

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet VAMP-2..

  1. 1. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

  3. 2. Proteins regulating vesicular docking and fusion : histochemical studies on their presence and regulation in endocrine, neuroendocrine and neuronal cells

    Författare :Gunilla Jacobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :- axotomy; botulinum neurotoxin; cranial nerve; CSP; ECL; endocrine; estrogen; exocytosis; hypothalamus; immunohistochemistry; in situ hybridization; motoneuron; mouse; mRNA; munc-18; pancreas; parasympathetic; pituitary; rat; salt-loading; sciatic n;

    Sammanfattning : Regulated transmitter release involves docking and fusion of transmitter-containing vesicles with the plasma membrane. Vesicular docking and fusion events are mediated by specific exocytotic proteins located at the vesicle membrane, in the cytoplasm or at the plasma membrane. LÄS MER

  4. 3. On the cholinergic c-bouton

    Författare :Johan Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; Brainstem; Immunohistochemistry; In situ hybridization; Motoneurons; Muscarinic receptors; Rat; Spinal cord; Ventral horn cells;

    Sammanfattning : The cholinergic C-bouton is a large nerve terminal type exclusively contacting motoneuron cell somata and proximal dendrites. C-boutons are characterized by subsurface cisterns found beneath the postsynaptic membrane, which is an exclusive feature for these nerve terminals. The origin of the C-boutons is unknown. LÄS MER

  5. 4. The role of T-type calcium channels in human pancreatic β cell maturity

    Författare :Kaixuan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets (hiPSC-islets). These approaches have also been applied to characterize hyperglycemia-induced dedifferentiation of mature β cells within native human islets grafted into the anterior chamber of the eye (ACE) of immunodeficient mice. LÄS MER

  7. 5. Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells

    Författare :Teresa Daraio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to address the metabolic syndrome are currently not optimal. LÄS MER