Sökning: "synaptotagmin III"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden synaptotagmin III.

  1. 1. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Författare :Sofia A Andersson; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER

  3. 2. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Författare :Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Sammanfattning : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. LÄS MER

  4. 3. Proteins regulating vesicular docking and fusion : histochemical studies on their presence and regulation in endocrine, neuroendocrine and neuronal cells

    Författare :Gunilla Jacobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :- axotomy; botulinum neurotoxin; cranial nerve; CSP; ECL; endocrine; estrogen; exocytosis; hypothalamus; immunohistochemistry; in situ hybridization; motoneuron; mouse; mRNA; munc-18; pancreas; parasympathetic; pituitary; rat; salt-loading; sciatic n;

    Sammanfattning : Regulated transmitter release involves docking and fusion of transmitter-containing vesicles with the plasma membrane. Vesicular docking and fusion events are mediated by specific exocytotic proteins located at the vesicle membrane, in the cytoplasm or at the plasma membrane. LÄS MER

  5. 4. Structural Insights into Botulinum Neurotoxins and the ALFA-tag System : Structural and Functional Studies of Proteins Related to the Botulinum Neurotoxins and Design of a Novel Epitope Tag

    Författare :Markel Martínez-Carranza; Pål Stenmark; Thomas Binz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; botulinum neurotoxin; Biochemistry; biokemi;

    Sammanfattning : This thesis is divided into two sections; the first part describes our work in the field of botulinum neurotoxins (presented in papers I, II, III, and manuscript IV) and the second part summarizes our work involving the design of a new biochemical tool (presented in paper V).Botulinum neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinum are the most poisonous substances known to date. LÄS MER

  7. 5. Unraveling pathogenic proteins and pathways in Alzheimer disease : a focus on proteomics

    Författare :Hazal Haytural; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is a multifactorial and complex neurodegenerative disorder. To date, different mechanisms, such as impairment of synaptic, mitochondrial and autophagic function, neuroinflammation and many more, are found to disrupt cellular homeostasis in AD brains. LÄS MER