Sökning: "CTLA4"
Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet CTLA4.
6. Which Genes are Involved? - Statistical Planning and Analysis of Human Genetic Samples
Sammanfattning : This thesis consists of six papers related to the statistical planning and analysis of human genetic samples. The first four mainly concern statistical methodology, while the last two are applied papers in genetics and medicin. In paper A an alternative method of estimating the locus specific sibling relative risk .lambda. LÄS MER
7. Clinical and genetical aspects of Celiac Disease
Sammanfattning : Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. LÄS MER
8. Dissecting the complexity of human susceptibility to Plasmodium falciparum malaria: genetic approaches
Sammanfattning : There are many aspects of the immunology of P. falciparum infection that are not understood. Genetic approaches are of great value for dissecting the complexity of immune responses to malaria in natura by providing new insights into molecular interactions between the parasite and the host. LÄS MER
9. FOXP3 and CTLA-4 : how isoforms regulate immunological tolerance
Sammanfattning : The maintenance of immunological tolerance is vital for preventing the immune system to damage normal tissues and physiological function of the body. CD4+FOXP3+ regulatory T (Treg) cells can suppress immune responses in a dominant manner and are essential for immunological tolerance. LÄS MER
10. Compartmentalisation of the immune response in human skin : cross-talk between dendritic cells and T cells in healthy conditions and in psoriasis
Sammanfattning : Human skin is highly compartmentalised and distinct subsets of dendritic cells (DCs) and T cells reside in epidermis and dermis. Alterations in the composition of DCs and T cells have been observed in psoriasis, a common cytokine-driven focal inflammatory skin disease. LÄS MER