Tools for digital twins in continuous downstream processing

Sammanfattning: Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.