Sökning: "Autophagosome"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet Autophagosome.
1. Membrane-remodeling by SNX18 in endosomal transport and autophagy
Sammanfattning : The intracellular space of eukaryotic cells is subdivided into functionally distinct membrane-enclosed organelles. Regulation of these intracellular membranes requires an intricate network of specialized lipids and proteins that maintain organellar integrity and mediate transport between organelles. LÄS MER
2. The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s disease
Sammanfattning : Even though Alzheimer’s disease (AD) was first described more than 100 years ago, we still have no treatment preventing the ongoing neurodegenerative process. Two major pathological hallmarks have been connected to AD: extracellular amyloid plaques (constituted by amyloid β-peptide – Aβ) and neurofibrillary tangles. LÄS MER
3. Pattern recognition and iNKT cell regulation of B cell activation
Sammanfattning : The immune system protects individuals against infections but can cause disease if the response is unbalanced. Immune responses include both innate and adaptive response, and these systems are connected. As the first line of defense, innate immune responses are immediately induced upon infection. LÄS MER
4. Regulation of autophagy and mTOR during Semliki Forest virus infection
Sammanfattning : Semliki Forest virus (SFV) infection causes dramatic changes to the infected cell. For example, synthesis of most cellular proteins shuts off within 4 hours. The cell launches an antiviral response, forms stress granules and, as we found in the work leading up to this thesis, accumulates autophagosomes. LÄS MER
5. B cell regulation in autoimmune disease
Sammanfattning : Our immune system protects us from both foreign antigens and self-derived autoantigens by sophisticated regulation. During an immune response, the innate and adaptive parts of the immune system closely collaborate at every stage of the response. LÄS MER
