Sökning: "endosomal transport"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden endosomal transport.

  1. 1. Membrane-remodeling by SNX18 in endosomal transport and autophagy

    Författare :Karin Håberg; Sven Carlsson; Geir Bjørkøy; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sorting nexin; SNX9-family; SNX18; endosomal transport; autophagy; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The intracellular space of eukaryotic cells is subdivided into functionally distinct membrane-enclosed organelles. Regulation of these intracellular membranes requires an intricate network of specialized lipids and proteins that maintain organellar integrity and mediate transport between organelles. LÄS MER

  3. 2. Oligonucleotide Complexes with Cell-Penetrating Peptides : Structure, Binding, Translocation and Flux in Lipid Membranes

    Författare :Luis Daniel Ferreira Vasconcelos; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; Large unilamellar vesicle; Membrane perturbation; Endosomal escape; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. LÄS MER

  4. 3. Structure, Mechanism, and Regulation of Sodium/Proton Exchangers

    Författare :Iven Winkelmann; Drew David; Rajini Rao; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sodium proton exchange; SLC9; structure; secondary active transport; membrane protein; Biochemistry; biokemi;

    Sammanfattning : Sodium/proton exchangers (NHEs) are secondary active transporters that are ubiquitously found in all kingdoms of life. They facilitate the exchange of protons for sodium ions or other inorganic ions across biological membranes, regulating pH, sodium levels, and osmotic pressure. LÄS MER

  5. 4. Non-canonical ATG8 conjugation in ESCRT-driven membrane remodeling processes

    Författare :Anastasia Knyazeva; Yao-Wen Wu; Richard Lundmark; Sascha Martens; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ATG8 conjugation; Endosomal Sorting Complex Required for Transport; membrane remodeling; chemical genetics;

    Sammanfattning : ATG8 family proteins have the unique ability to conjugate to membrane lipids. Initially identified as a hallmark of autophagy, ATG8 lipidation is emerging as an important regulator of a growing list of non-degradative cellular functions. LÄS MER

  7. 5. Complexes of cell-penetrating peptides with oligonucleotides : Structure, binding and translocation in lipid membranes

    Författare :Luis Daniel Ferreira Vasconcelos; Ülo Langel; William C. Wimley; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; oligonucleotide; transfection; non-covalent complexes; membrane interaction; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The fundamental element of life known to man is the gene. The information contained in genes regulates all cellular functions, in health and disease. The ability to selectively alter genes or their transcript intermediates with designed molecular tools, as synthetic oligonucleotides, represents a paradigm shift in human medicine. LÄS MER