Sökning: "phosphotyrosine"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet phosphotyrosine.

1. 1. New fractionation tools targeting elusive post-translational modifications

   Författare :Celina Wierzbicka; Malmö högskola; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular imprinting; Molecular recognition; Phosphopeptides; Proteomics; Phosphotyrosine; Phosphohistidine;

   Sammanfattning : Protein phosphorylation is a reversible post-translational modification (PTM)playing a central role in numerous biological events including disease pathogenesis.Thus, the analysis of phosphoproteome is crucial for understandingcellular regulation processes and can facilitate the development of new diagnosticand therapeutic tools. LÄS MER

3. 2. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

   Författare :Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. LÄS MER

4. 3. POROUS POLYMERS AND DESIGNED SORBENTS FOR APPLICATIONS IN BIOMEDICAL RESEARCH

   Författare :Mariana Duarte; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :polymers; sorbents; polymer porosity; selective extraction; biomarkers; molecularly imprinted polymers;

   Sammanfattning : Everyday millions of bioanalyses are performed in clinical laboratories, hospitals and research centers, where technicians and bio-analysts utilize analytical chemistry principles and instruments to serve medicine and biomedical research. A method routinely used for sample preparation in bioanalysis is solid-phase extraction (SPE). LÄS MER

5. 4. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

   Författare :Kristina Holmqvist; Michael Welsh; Eva Degerman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. LÄS MER

7. 5. Alterations in receptor expression and function in scrapie-infected neuronal cell lines

   Författare :Heléne Lindegren; Katarina Bedecs; David Brown; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurobiology; Neurobiologi;

   Sammanfattning : This study shows that lipopolysaccharide (LPS) induces a robust, concentration-and time-dependent increase in nitric oxide (NO) production in the murine neuroblastoma cell line N2a by increased expression of iNOS. However, in scrapie-infected N2a cells (ScN2a), the LPS-induced NO production was completely abolished. LÄS MER