Sökning: "amphetamine"

Visar resultat 1 - 5 av 79 avhandlingar innehållade ordet amphetamine.

  1. 1. Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat

    Författare :Amir Lotfi Moghaddam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; withdrawal; nicotine; amphetamine; striatum; GABA; glutamate; dopamine; sensitization; locomotor activity;

    Sammanfattning : Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development of habitual and compulsive behavior, namely subregions of striatum in the rat. LÄS MER

  3. 2. Neurobiological Consequences of Social Conditions and Alcohol Exposure in Adolescent rats

    Författare :Linnea Granholm; Ingrid Nylander; Anne-Lie Svensson; Erika Roman; Maria Ellgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; alcohol; amphetamine; dopamine; dorsal striatum; dynorphin; endogenous opi- oids; enkephalin; high-speed chronoamperometry; housing conditions; rats; nociceptin orphanin FQ; radi- oimmunoassay; self-administration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Adolescence represents a time of extensive reorganisation and maturation of brain circuits involved in emotions, motivation and cognition and it is a period particular sensitive for external stimuli. External stimuli can be both socio-environmental factors and exposure to exogenous compounds such as drugs of abuse (e.g. alcohol). LÄS MER

  4. 3. Nicotine sensitization and loss of inhibitory control. Role of serotonin

    Författare :Peter Olausson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nicotine; Amphetamine; Locomotor activity; Inhibitory control; Dopamine; Serotonin; Sensitization; Nucleus accumbens; Elevated plus-maze;

    Sammanfattning : Drug dependence is a devastating disorder present in all parts of the world. It is manifested by craving and a general loss of control over the drug intake and the life situation, ultimately leading to compulsive use of the addictive drug at the expense of normal behavioral patterns. LÄS MER

  5. 4. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

    Författare :Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

    Sammanfattning : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. LÄS MER

  7. 5. Stress, Drugs and Neuroscience : Neurobiological Effects of Social Stressors and Drug Exposure in Young and Adolescent Rats

    Författare :Linnea Granholm; Ingrid Nylander; Erika Roman; Anne-Lie Svensson; Maria Ellgren; Annika Thorsell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adolescence; alcohol exposure; amphetamine; beta-endorphin; dopamine; dynorphin; early life; endogenous opioids; enkephalin; gene expression; high-speed chronoamperometry; nociceptin orphanin FQ; radioimmunoassay; self-administration; social stress; voluntary alcohol intake; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual. LÄS MER