Sökning: "tyrosine kinases"

Visar resultat 16 - 20 av 138 avhandlingar innehållade orden tyrosine kinases.

1. 16. Structural and Functional Studies of Gas6

   Författare :Jonas Stenhoff; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; EDTA; calcium; multimer; monomer; platelets; Mer; Axl; vitamin K; Gas6; human circulation; soluble receptor; Tyro3; receptor tyrosine kinases; growth factor;

   Sammanfattning : The vitamin K-dependent and ubiquitously expressed 82 kDa glycoprotein product of the growth-arrest-specific-gene 6, Gas6, shows 44% sequence identity to the anticoagulant protein, protein S. Both proteins share further the same domain organization. LÄS MER

3. 17. Subcellular localization and signalling of Brutons tyrosine kinase (Btk)

   Författare :Leonardo Vargas-Vallejo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :B-cells; Brutons tyrosine kinase; X-linked agammaglobulinemia; pleckstrin homology domain; cytoskeleton; nucleocytoplasmic shuttling; caveolin-1; ubiquitin; SUMO-1.;

   Sammanfattning : Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related to the Src family of kinases. Mutations in various parts of the gene have been shown to cause X-linked agammaglobulinemia (XLA), a primary immunodeficiency in humans, characterized by a defect in B-cell development. LÄS MER

4. 18. Receptor tyrosine kinases and circulating tumor cells as new prognostic biomarkers in breast cancer with special focus on TNBC

   Författare :Sara Jansson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bröstcancer;

   Sammanfattning : About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. LÄS MER

5. 19. New Diagnostic and Therapeutic Approaches in Adrenocortical Cancer

   Författare :Tanweera Shaheena Khan; Barbro Eriksson; Mats Bergström; Anna-Lena Hulting; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Adrenocortical cancer; Positron Emission Tomography; Metomidate; Combination chemotherapy; Streptozocin; op -DDD; OPEC; Disease-free Interval; Survival; Responses; Side effects; Receptor protein-tyrosine kinases; c-Kit; Phospho-c-Kit; PDGFRβ; Mutation; Imatinib; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : Adrenocortical cancer (ACC) is a rare disease that is often difficult to diagnose, and therefore often presents at an advanced stage. Various cytotoxic treatments have been tried with little success. Evaluation of new diagnostic methods and improvement of medical therapies are therefore crucial. LÄS MER

7. 20. Ischemic Tolerance and Cell Signaling in the Rat Brain

   Författare :Mehrdad Shamloo; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; preconditioning; cell death; tyrosine phosphorylation; tolerance; ERK; Calpain; CaMKII; PKC; protection; Brain; ischemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : A brief period of sublethal ischemia in the brain induces resistance to a subsequent, otherwise lethal ischemic insult. This phenomenon is known as ischemic tolerance or preconditioning. A model of ischemic preconditioning in the rat brain using the two-vessel occlusion model of global cerebral ischemia was established. LÄS MER