Sökning: "Combination chemotherapy"

Visar resultat 1 - 5 av 166 avhandlingar innehållade orden Combination chemotherapy.

1. 1. Combination chemotherapy for human immunodeficiency virus infection

   Författare :Sarah Palmer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The worldwide spread of human immunodeficiency virus (HIV) has spurred the search for effective drugs to combat this deadly virus. The limited effect of monotherapy treatment, in large measure due to the development of drug resistant viral strains, has led to increased emphasis on combination chemotherapy for the treatment of HIV, the focus of this study. LÄS MER

3. 2. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Författare :Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. LÄS MER

4. 3. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

   Författare :Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

   Sammanfattning : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. LÄS MER

5. 4. Clinical and Experimental Studies in Peritoneal Metastases from Gastric Cancer

   Författare :Bo Hultman; Haile Mahteme; Bruno Walther; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastric cancer; peritoneal metastases; peritoneal carcinomatosis; epidemiology; prognostic factor; survival; neoadjuvant chemotherapy; cytoreductive surgery; HIPEC; health economy; costs; systemic chemotherapy; cultured tumor cells; fluorometric analysis; cancer drug tests; chemo-sensitivity; anti tumor drugs.; Surgery; Kirurgi;

   Sammanfattning : Gastric cancer (GC) is one of leading causes of death in the world, and peritoneal metastases (PM) are a major site of recurrence. PM from GC implies a poor prognosis, with median overall survival (mOS) approximately 3 months and no survival at five years. LÄS MER

7. 5. Chemosensitivity in Breast Cancer

   Författare :Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
   Nyckelord :Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

   Sammanfattning : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. LÄS MER