Sökning: "tyrosine kinases"

Visar resultat 11 - 15 av 138 avhandlingar innehållade orden tyrosine kinases.

  1. 11. Tec family kinases : transcriptional and posttranslational regulation

    Författare :Liang Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tec family tyrosine kinases consist of five members: Btk, Itk, Tec, Rlk/Txk and Bmx. These kinases are highly expressed in hematopoietic cells, including B cells, T cells and mast cells. LÄS MER

  3. 12. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Författare :Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Sammanfattning : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. LÄS MER

  4. 13. Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development

    Författare :Christina Lorén; Mike Taylor; Umeå universitet; []
    Nyckelord :DAlk; receptor tyrosine kinase; Jeb; visceral muscle fusion; ERK; Drosophila; endoderm; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (DAlk) is homologous to mammalian Alk, which is a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans the t(2;5) translocation involving the Alk locus encodes an active form of Alk that is the causative agent in Non-Hodgkin’s Lymphoma (Morris et al., 1994). LÄS MER

  5. 14. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer

    Författare :Cynthia Veenstra; Olle Stål; Gizeh Perez-Tenorio; Pietras Kristian; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. LÄS MER

  7. 15. Targeting EGFR and VEGFR2 tyrosine kinases with positron emission tomography : evaluation of two radiotracers

    Författare :Erik Samén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Receptor tyrosine kinases (RTKs) are commonly involved in the development, growth and spread of cancer. Targeted therapy with tyrosine kinase inhibitors (TKIs) has proven a successful treatment strategy against cancers in which growth is dependent on the expression of these receptors. LÄS MER