Sökning: "solid dispersion"

Visar resultat 1 - 5 av 97 avhandlingar innehållade orden solid dispersion.

1. 1. Dispersion of wood fuel in a stationary fluidized

   Författare :Fredrik Niklasson; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; boiler; fluidized bed; solid mixing; lateral dispersion;

   Sammanfattning : .... LÄS MER

3. 2. Phase Transformations in Solid Pharmaceutical Materials Studied by AFM, ESCA, DSC and SAXS

   Författare :Denny Mahlin; Göran Alderborn; Sven Engström; Duncan Q M Craig; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; polymer; lipid; lactose; phase transformation; phase formation; crystallisation; AFM; X-ray diffraction; ESCA; DSC; solid dispersion; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi;

   Sammanfattning : Mixing excipients is a common way to produce pharmaceutical materials with suitable properties for drug formulation. An understanding of the basic mechanisms involved in the formation and transformation of the structures of solid state mixtures is crucial if one is to be able to produce materials with the desired properties in a reliable way. LÄS MER

4. 3. Characterisation of Aqueous Solutions, Liquid Crystals and Solid State of Non-ionic Polymers in Association with Amphiphiles and Drugs

   Författare :Annika Ridell; Martin Malmsten; Sven Engström; David Attwood; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; polymer; surfactant; phase diagram; x-ray diffraction; fluorescence spectroscopy; calorimetry; PEG; cellulose ether; viscometry; cubic phase; liquid crystals; drugs; solid dispersion; Fysikalisk kemi; Physical chemistry; Fysikalisk kemi; Fysikalisk och oorganisk farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry;

   Sammanfattning : Cellulose ethers and polyethylene glycols are used in drug formulations as water swelling or water soluble matrices. Polar lipids, for example monoglycerides, and surfactants can be used to solubilise hydrophobic or amphiphilic drugs and to formulate potential drug delivery vehicles such as emulsions, liposomes and cubic phases. LÄS MER

5. 4. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

   Författare :Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
   Nyckelord :Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. LÄS MER

7. 5. Multiscale X-ray Characterisation of Cellulose-based Solid Dispersions

   Författare :Martina Olsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PXCT; WAXS; pharmaceutical formulations; multiscale characterisation; STXM; radiation damage; SAXS; X-ray imaging; solid dispersions; cellulose;

   Sammanfattning : Cellulose-based solid dispersions are a promising formulation strategy for providing controlled drug release and dissolution enhancement of poorly soluble drugs. These dispersions can from structures on multiple length scales which can have both positive and negative effects on the functional properties of the formulation. LÄS MER