Sökning: "peptide grafting"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden peptide grafting.
1. Cyclic peptides as biological tools : Applications for diagnosis and therapeutics in rheumatoid arthritis and COVID-19
Sammanfattning : The overall aims of the projects included in this thesis were to design, synthesize and evaluate cyclic peptide scaffolds grafted with biological epitopes for their ability to bind antibodies in rheumatoid arthritis and COVID-19 sera. One of the main outcomes of this thesis was the observation that scaffold peptides grafted with target epitopes efficiently neutralized anti-citrullinated protein autoantibodies (ACPA) from rheumatoid arthritis patients. LÄS MER
2. On the Design of Affibody Molecules for Radiolabeling and In Vivo Molecular Imaging
Sammanfattning : Affibody molecules have lately shown great potential as tools for in vivo molecular imaging. These small, 3-helical bundles, with their highly stable protein scaffold, are well suited for the often harsh conditions of radiolabeling. LÄS MER
3. HYDROPHOBIC PEPTIDE TAGS - As tools in bioseparation and investigation of recombinant proteins
Sammanfattning : This thesis describes the possibility of using hydrophobic peptide tags as tools for bioseparation and for the investigation of recombinant proteins. The hydrophobicity of a protein can easily be changed by minor modifications, such as fusions of tyrosine-containing peptides. LÄS MER
4. Blood pressure-dependent changes in plasma volume, glycocalyx and platelet function during anaesthesia -Clinical and experimental studies
Sammanfattning : Background: Worldwide, more than 300 million surgeries are performed each year. General anaesthesia provides the surgical patient with a state of controlled loss of sensation and awareness. It is common that general anaesthesia causes hypotension. Anaesthesia-induced hypotension is associated with haemodilution and increased plasma volume (PV). LÄS MER
5. Neurohormonal Modulators in the Parathyroid Gland. Localization and regulation
Sammanfattning : The occurrence and distribution of neurohormonal peptides, neuroendocrine markers and receptors in parathyroid nerve fibers and endocrine cells are described, using immunocytochemistry, in situ hybridization, image analysis and reverse transcriptase polymerase chain reaction. Immunocytochemical studies revealed that parathyroid glands of chicken, rat, guinea-pig, cat, dog and sheep contained adrenergic-, cholinergic-, and peptide-containing nerve fibers. LÄS MER