Sökning: "observational"

Visar resultat 1 - 5 av 765 avhandlingar innehållade ordet observational.

  1. 1. Benefits and harms of Bisphosphonates : an observational study

    Författare :Jonathan Bergman; Peter Nordström; Miia Kivipelto; Håkan Melhus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; fracture; alendronate; risedronate; zoledronic acid; glucocorticoid; mortality; osteonecrosis; register; registry; real-world evidence; epidemiology; Geriatrics; geriatrik; epidemiologi; Epidemiology;

    Sammanfattning : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. LÄS MER

  3. 2. Design and analysis with observational data : Protocols and modeling with the aim of causal inference

    Författare :Paulina Jonéus; Mattias Nordin; Per Johansson; Jenny Häggström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; observational studies; protocols guidelines; epidemiology; public health; prostate disease; Statistics; Statistik;

    Sammanfattning : This thesis consists of six papers that study the design and analysis with observational data.There is a growing interest in using real-world evidence (RWE) for regulatory purposes. The belief is that observational data can make drug developmentmore efficient and speed up patient access to new drugs. LÄS MER

  4. 3. Geotechnical risk management using the observational method

    Författare :Mats Tidlund; Stefan Larsson; Johan Spross; Håkan Stille; Jan Bröchner; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; risk; risk management; geotechnical engineering; contractual framework; observational method; risk; riskhantering; geoteknik; kontrakt; observationsmetoden; Soil and Rock Mechanics; Jord- och bergmekanik;

    Sammanfattning : There have been many cost overruns, time delays and quality problems reported from geotechnical engineering projects around the world during recent decades. Many of the reported problems are associated with risks related to the geotechnical conditions. LÄS MER

  5. 4. Dietary Fatty Acids and Inflammation : Observational and Interventional Studies

    Författare :Helena Bjermo; Ulf Risérus; Tommy Cederholm; Parveen Yaqoob; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dietary fat; Fatty acids; Serum fatty acid composition; Linoleic acid; Stearoyl coenzymeA desaturase; SCD-1; Inflammation; C-reactive protein; Oxidative stress; Lipid peroxidation; Isoprostanes; Prostaglandins; Obesity; Epidemiology; Dietary intervention; Metabolic syndrome; Nutrition; Näringslära; Epidemiology; Epidemiologi; Public health science; Folkhälsovetenskap; Immunology; Immunologi; Diabetology; Diabetologi; Cardiology; Kardiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Dietary fat quality influences the risk of type 2 diabetes and cardiovascular disease. A low-grade inflammation is suggested to contribute to the disease development, often accompanied by obesity. Whereas n-3 polyunsaturated fatty acids (PUFA) have been considered anti-inflammatory, n-6 PUFA have been proposed to act pro-inflammatory. LÄS MER

  7. 5. Dietary Intake, Fatty Acid Biomarkers, and Abdominal Obesity : Population-Based Observational Studies

    Författare :Zayed Alsharari; Ulf Risérus; Matti Marklund; Per Sjögren; Tommy Cederholm; Emily Sonestedt; Uppsala universitet; []
    Nyckelord :abdominal obesity; fatty acid biomarker; dietary intake; Kostvetenskap; Food; Nutrition and Dietetics;

    Sammanfattning : The aim of this thesis was to investigate the associations between fatty acid (FA) biomarkers, carbohydrate intake, and abdominal obesity (AO) and related anthropometric measures in a population-based cohort of men and women in Stockholm County. The overall hypothesis was that dietary fat quality assessed by serum and adipose tissue FA composition, and dietary intake of especially carbohydrates is associated with AO. LÄS MER