Sökning: "neurodegenerative disease"

Visar resultat 31 - 35 av 436 avhandlingar innehållade orden neurodegenerative disease.

  1. 31. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

    Författare :Erik Stomrud; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

    Sammanfattning : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. LÄS MER

  3. 32. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 : Two key players in Alzheimer’s disease

    Författare :Preeti Menon; Anna-Lena Ström; Thorsten Müller; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; APP; Fe65; Meprinβ; α-secretase; APP processing; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. LÄS MER

  4. 33. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    Författare :Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. LÄS MER

  5. 34. Proteomics in neurological disease

    Författare :Jan Ottervald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodegenerative and neuroinflammatory diseases are conditions affecting the central nervous system that in the end have dramatic impacts on the affected individuals and their families. Today, large efforts are made to understand the disease origin and progression. LÄS MER

  7. 35. Allergy and Alzheimer disease

    Författare :Heela Sarlus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive dementia with devastating effects for the patients and their families. The treatments available are purely symptomatic and there is need for treatment strategies aiming at the etiopathogenesis of AD. LÄS MER