Sökning: "neurodegenerative disease"

Visar resultat 21 - 25 av 436 avhandlingar innehållade orden neurodegenerative disease.

  1. 21. Peripheral apolipoprotein E and its emerging role in neurodegenerative disease

    Författare :Andreas Giannisis; Henrietta M. Nielsen; Kim Kultima; Johan Ankarklev; Cheryl Wellington; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; humanized-liver mice; race; diet; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The human apolipoprotein E gene (APOE) is polymorphic and coding for three common alleles; ε2, ε3, and ε4. Carriers of the ε4 allele are at a higher risk of developing sporadic late-onset Alzheimer’s Disease (AD). This association appears to be influenced by inherited traits, race, and sex. LÄS MER

  3. 22. Mitochondrial dysfunction and metabolic intervention

    Författare :Johannes Ehinger; Mitokondriell Medicin; []
    Nyckelord :Mitochondrial Diseases; Huntington Disease; Amyotrophic lateral sclerosis; Succinate; Neurodegenerative disease; Inborn errors of metabolism; Mitochondria; Animal models;

    Sammanfattning : .... LÄS MER

  4. 23. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

    Författare :Jakob Domert; Martin Hallbeck; Jan Marcusson; Lars Tjernberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-to-cell transfer; beta-amyloid; Alzheimer s disease; degradation; proteasome; alpha-synuclein; Parkinson s disease; high throughput screening model;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. LÄS MER

  5. 24. Towards Clinical Implementation of Dynamic Positron Emission Tomography in Neurodegenerative Diseases

    Författare :My Jonasson; Mark Lubberink; Lieuwe Appel; Jens Sörensen; Michel Koole; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; Molecular imaging; Quantification; Kinetic modelling; Parametric images; Alzheimer’s disease; Parkinson’s disease; Radiology; Radiologi;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders worldwide. Positron emission tomography (PET), together with suitable biomarkers, can aid in the clin-ical evaluation as well as in research investigations of these diseases. LÄS MER

  7. 25. Modeling of biomembranes: from computational toxicology to simulations of neurodegenerative diseases

    Författare :Inna Ermilova; Alexander Lyubartsev; Marta Pasenkiewicz-Gierula; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomembranes; lipid bilayers; Alzheimer s disease; Parkinson disease; computational toxicology; passive diffusion; hydroxylated polybrominated diphenyl ethers; omega-3; omega-6; amyloid beta peptide; molecular dynamics simulations; SLipids force field; fysikalisk kemi; Physical Chemistry;

    Sammanfattning : It was known from the middle of the last century that a cell-membrane is a lipid bilayer. Since that time a large number of experimental studies has been done in order to see how a certain molecule can penetrate through a membrane. LÄS MER