Sökning: "lipotoxicity"

Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet lipotoxicity.

1. 6. Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets

   Författare :Sandra Meidute; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hormone secretion; cell stress; Pancreatic beta-cell; cellular signalling; GPR40; diabetes;

   Sammanfattning : Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-cell function during both short-term as well as long-term exposure. LÄS MER

3. 7. Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease

   Författare :Annika Mehlem; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Vascular Endothelial Growth Factor B (VEGF-B) was previously shown to control lipid uptake from the bloodstream via the endothelium into tissue cells, and when ablating Vegfb, intra-tissue lipid accumulation was reduced. However, very little is known regarding the metabolic role of VEGF-B in physiologic, or pathophysiologic conditions. LÄS MER

4. 8. Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression

   Författare :Hamedeh Ghanaat-pour; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. The primary pathogenesis of T2D probably involves both genetic and environmental forces, and hyperglycemia and very commonly hyperlipidemia might further aggravate beta-cell dysfunction. LÄS MER

5. 9. Metabolic aspects of cardiac arrhythmias

   Författare :Sigfus Gizurarson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiologi; Electrofysiologi; Djurexperiment; Metabolism;

   Sammanfattning : Cardiac arrhythmias are an important cause of mortality and morbidity in patients with cardiac diseases. Sudden death due to ventricular tachycardia and fibrillation (VT/VF) in the setting of acute myocardial infarction (AMI) and heart failure (HF) is a frequent cause of premature death. LÄS MER

7. 10. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

   Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

   Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER