Sökning: "Pancreatic beta-cell"

Visar resultat 1 - 5 av 116 avhandlingar innehållade orden Pancreatic beta-cell.

1. 1. Studies of sulfatide expression in relation to beta cell function

   Författare :Maria K. Blomqvist; Göteborgs universitet; []
   Nyckelord :sulfatide; glycosphingolipid; insulin; beta cell; diabetes mellitus; animal models; ; beta cell line;

   Sammanfattning : Previous studies have shown that the glycosphingolipid sulfatide (3´-sulfogalactosyl-ceramide) is present and functionally involved in pancreatic beta cells. In these cells, sulfatide is synthesised as two major isoforms, C16:0 and C24:0 sulfatide, with different length of the fatty acid chain of the ceramide moiety. LÄS MER

3. 2. Maf transcription factors in beta cell function

   Författare :Elvira Ganic; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

   Sammanfattning : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. LÄS MER

4. 3. PET imaging of beta-cell mass

   Författare :Pierre Cheung; Olof Eriksson; Weibo Cai; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; diabetes; beta-cell mass; affibody; SC-islets; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : A hallmark of diabetes is the progressive loss of the beta-cell mass (BCM) and function. Most of the diagnostic methods for diabetes are mostly reflective of the beta-cell function, whereas current methodologies for studying the beta-cell mass are limited to post-mortem biopsies or highly invasive methods. LÄS MER

5. 4. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

   Författare :Sara Ullsten; Per-Ola Carlsson; Joey Lau; Sara Bohman; Rebecca L. Hull; Uppsala universitet; []
   Nyckelord :Pancreatic islets; heterogeneity; islet vascularity; blood flow; islet transplantation; islet amyloid; insulitis; type 1 diabetes; beta cell proliferation; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. LÄS MER

7. 5. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

   Författare :Alexander Balhuizen; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

   Sammanfattning : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). LÄS MER