Sökning: "intrinsic solubility"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden intrinsic solubility.
1. Computational Analysis of Aqueous Drug Solubility – Influence of the Solid State
Sammanfattning : Aqueous solubility is a key parameter influencing the bioavailability of drugs and drug candidates. In this thesis computational models for the prediction of aqueous drug solubility were explored. LÄS MER
2. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs
Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER
3. Defect Engineering in Kesterite Materials for Thin Film Solar Cells
Sammanfattning : Cu2ZnSnS4 has great potential to be applied as an earth abundant and non-toxic absorber material in thin film solar cells, based on its suitable optical properties. However, several challenges have prevented the achievable efficiencies from exceeding 12.6 %, which is well below marketable efficiencies compared to competing solar cell technologies. LÄS MER
4. Electronic Structure Calculations of Point Defects in Semiconductors
Sammanfattning : In this thesis point defects in semiconductors are studied by electronic structure calculations. Results are presented for the stability and equilibrium concentrations of native defects in GaP, InP, InAs, and InSb, for the entire range of doping conditions and stoichiometry. LÄS MER
5. The effects of solid state properties on solubility and "in vitro" dissolution behaviour of suspended sparingly soluble drugs
Sammanfattning : The solubility and dissolution behaviour of hydrophobic and hydrophilic sparingly soluble drugs is discussed in this thesis. The roles of varying particle dimensions, disordered (amorphous) solid structures and the coexistence of amorphous and crystalline phases, especially on the surfaces of particles with a crystalline core, are evaluated in this context. LÄS MER