Sökning: "indirect-response model"
Hittade 5 avhandlingar innehållade orden indirect-response model.
1. Pharmacokinetic and pharmacodynamic analysis of antidiuretic peptides
Sammanfattning : The clinical pharmacology of desmopressin and a new vasopressin analogue (F992) was investigated in healthy human subjects. The common procedure of overhydration of healthy volunteers when studying the antidiuretic effect of a drug, may affect the pharmacokinetics, in particular the volumes of distribution. LÄS MER
2. Studies on intrinsic and extrinsic sources of variability in pharmacokinetics and pharmacodynamics
Sammanfattning : Variability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. LÄS MER
3. Uptake and toxicity of brominated flame retardants and pesticides : Studies on littoral organisms and model communities
Sammanfattning : In this thesis, brackish and freshwater littoral model communities (microcosms) of varying size and complexity were used to study the effects of brominated flame retardants (BFRs) and pesticides. The brackish water microcosms consisted of natural water, sediment and associated organisms, while the larger freshwater microcosms also contained submersed macrophytes (Elodea canadensis). LÄS MER
4. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection
Sammanfattning : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. LÄS MER
5. Furosemide dosage input : consequences for diuretic effect, tolerance and efficiency
Sammanfattning : The development of new dosage forms raises the question of how the pharmacokinetic pharmacodynamic (PK-PD) profile of a drug is influenced by the drug input rate. Furosemide was used as a model drug to study the relationship between drug input rate and effect. LÄS MER