Sökning: "erythromycin"

Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet erythromycin.

  1. 1. Pharmacokinetic and pharmacodynamic analysis of antidiuretic peptides

    Författare :Torbjörn Callréus; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lithium; indirect-response model; pharmacodynamics; pharmacokinetics; gastrointestinal absorption; gastrointestinal motility; loperamide; erythromycin; antidiuretic effect; desmopressin; overhydration; vasopressin analogue F992 ; interaction; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The clinical pharmacology of desmopressin and a new vasopressin analogue (F992) was investigated in healthy human subjects. The common procedure of overhydration of healthy volunteers when studying the antidiuretic effect of a drug, may affect the pharmacokinetics, in particular the volumes of distribution. LÄS MER

  3. 2. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs

    Författare :Elin Matsson; Hans Lennernäs; Lars Knutson; Ulf Eriksson; Kim Brouwer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Direct thrombin inhibitors; prodrugs; ximelagatran; AZD0837; erythromycin; ketoconazole; drug-drug interactions; hepatobiliary transport; biliary clearance; ATP-binding cassette; ABC transporters; solute carriers; SLC transporters; CYP3A4; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Sammanfattning : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. LÄS MER

  4. 3. Group A Streptococci; Epidemiology and Genetics of Antibiotic Resistance

    Författare :Aftab Jasir; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; typing; epidemiology; M protein; emm gene; erythromycin; tetracycline; macrolides; streptococci; antibiotics; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology;

    Sammanfattning : Group A streptococci (GAS) cause throat and skin infections, severe invasive diseases as well as the non-suppurative complications acute rheumatic fever and glomerulonephritis. GAS have retained susceptibility to betalactam drugs, but resistance to alternative antibiotics is of concern. LÄS MER

  5. 4. Antibiotics and infusion phlebitis. Clinical and experimental studies

    Författare :Peter Lanbeck; Enheten för infektionssjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infections; HUVEC; endothelium vascular; Infektioner; ICAM-1; 3H-thymidine incorporation; cloxacillin; dicloxacillin; phlebitis epidemiology; Antibiotics; phlebitis chemically induced;

    Sammanfattning : Intravenous administration of antibiotics is often followed by infusion phlebitis. In this condition are vessel irritation, inflammation and sometimes superficial thrombosis included. In this thesis, the risk for infusion phlebitis for various antibiotics has been evaluated in a clinical study in 550 patients. LÄS MER

  7. 5. Macrolide Antibiotics in Bacterial Protein Synthesis

    Författare :Martin Lovmar; Måns Ehrenberg; Tanel Tenson; Peter B. Moore; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein synthesis; macrolides; resistance; initiation of translation; non-competitive inhibitors; kinetics; translation accuracy; proof-reading; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Macrolides are a large group of clinically relevant antibiotics that inhibit protein synthesis by binding to the large ribosomal subunit in the peptide exit tunnel, close to the peptidyl transferase center (PTC). We have shown that the peptide length of the resulting peptidyl-tRNA drop-off products is proportional to the distance between the PTC and the respective macrolide in the tunnel. LÄS MER