Sökning: "immune regulation"

Visar resultat 21 - 25 av 683 avhandlingar innehållade orden immune regulation.

  1. 21. Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes

    Författare :Alireza Labani Motlagh; Lucia Mincheva-Nilsson; Ola Winqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; EOC; HGSC; exosomes; NKG2D; MICA B; ULBP; DNAM-1; PVR; nectin-2; lncRNAs; immune suppression; anti-tumor immunity; NK-cell cytotoxicity; cytokines; Th1; Th2; T regulatory response; inflammation; tumor microenvironment;

    Sammanfattning : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. LÄS MER

  3. 22. The interplay between Giardia intestinalis and host intestinal epithelial cells : A tale of immune activation and suppression

    Författare :Jana Grüttner; Staffan Svärd; Mikael E. Sellin; Steven Singer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giardia; diarrhea; RNAseq; proteomics; small intestinal epithelial cells; enteroids; organoids; protozoan; differentiation; immune response; host-parasite interaction; swimming; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Giardia intestinalis is a non-invasive, protozoan parasite causing the diarrheal disease giardiasis in a variety of mammals, including humans. The parasite has two main life cycle stages; disease-causing trophozoites and infectious cysts. Trophozoites colonize the host’s upper small intestine by attaching to intestinal epithelial cells (IECs). G. LÄS MER

  4. 23. RNA-based mechanisms of chromatin and gene regulation

    Författare :Jordi Planells Rodrigo; Neus Visa; Simon Elsässer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Gene regulation; chromatin; non-coding RNAs; genome-wide studies; Drosophila melanogaster; ADAR3; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Cells regulate gene expression in a particular spatio-temporal manner by executing specific transcriptional programs. The different transcriptional programs allow the generation of the different cell types in multicellular organisms and mediate particular cellular responses to external cues such as viral infections. LÄS MER

  5. 24. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

    Författare :Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

    Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER

  7. 25. Innate regulation of the adaptive immune system during autoimmunity

    Författare :Roham Parsa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immune activation comprises multiple biological checkpoints to ensure proper and regulated effector functions. Phagocytes such as macrophages, dendritic cells and neutrophils have important functions during inflammation, e.g. clearance of bacterial pathogens. LÄS MER