Sökning: "26S"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet 26S.

  1. 1. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

    Författare :Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

    Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER

  3. 2. A Study on Trypanosomal Polyamine Biosynthetic Enzymes

    Författare :Sima Nasizadeh; Biogena aminer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell cycle; protein turnover; trypanosomatids; polyamines; Ornithine decarboxylase; S-adenosylmethione decarboxylase; Parasitology human and animal ; Parasitologi människa och djur ;

    Sammanfattning : The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. LÄS MER

  4. 3. Studies of metazoan proteasome function and regulation

    Författare :Josefin Lundgren; Patrick Young; Michael Glickman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteasome ubiquitin RNAi microarray; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Biological processes depend upon the structural and functional quality of the molecules that comprise living organisms. The integrity of molecules such as DNA, RNA, proteins, carbohydrates and lipids is crucial and the precise three-dimensional shape and the detailed chemistry of these molecules orchestrate the biochemical processes vital for life. LÄS MER

  5. 4. Identification and characterization of a proteasome deubiquitinase inhibitor

    Författare :Slavica Brnjic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has clinically validated the 26S proteasome as a therapeutic target in oncology. LÄS MER

  7. 5. Mechanisms of regulation of dioxin receptor function

    Författare :Maria Lindebro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The dioxin receptor is a ligand-inducible transcription factor that belongs to the basic helix-loop- helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The dioxin receptor is regulated in a spatial manner, where the unliganded dioxin receptor resides in the cell cytoplasm in a complex with heat shock protein 90 (hsp90). LÄS MER