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  1. 1. Epigenetic Regulation of Light and Hormonal Signaling in Arabidopsis thaliana

    Författare :Kristina Rizzardi; Annika Sundås-Larsson; Katarina Landberg; Johan Memelink; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TERMINAL FLOWER2; auxin; jasmonate; epigenetics; photomorphogenesis; Plant physiology; Växtfysiologi; Biologi med inriktning mot fysiologisk botanik; Biology with specialization in Physiological Botany;

    Sammanfattning : Plants are stationary and need to adapt to the environment they live in. Integration of environmental cues, such as changes in light and temperature, can occur either directly or through the action of hormones. Hormone and light signaling leads to rapid changes in gene expression, and eventually changes in protein levels. LÄS MER

  3. 2. The role of leptin in endothelial dysfunction and cardiovascular disease

    Författare :Manuel Cruz Gonzalez Garcia; Stefan Söderberg; Jan Engvall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leptin; obesity; endothelial dysfunction; cardiovascular disease; kardiologi; Cardiology;

    Sammanfattning : Objective:  Obesity has become the leading cause of mortality worldwide; however, the fundamental pathophysiology underlying this association remains unclear. The discovery of adipokines, i.e., cytokines produced by adipose cells (adipocytes), revealed that adipose tissue is a highly endocrine organ, thus opening new lines of investigation. LÄS MER

  4. 3. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

    Författare :Elisabeth Björntorp Mark; Göteborgs universitet; []
    Nyckelord :IGF1R; GH; Id1; keratinocytes; psoriasis;

    Sammanfattning : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. LÄS MER

  5. 4. Metabolic Effects of Growth Hormone Replacement Therapy in Adults - with Special Reference to Insulin Sensitivity

    Författare :Mikael Segerlantz; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; Endokrinologi; sekretion; diabetologi; cortisol replacement; lipid oxidation; glucose metabolism; glucose uptake; insulin resitance; GH; insulin sensitivity; GH deficiency;

    Sammanfattning : A risk for premature atherosclerosis and increased cardiovascular mortality has been reported in adult patients suffering from growth hormone deficiency (GHD) and receiving conventional hormone substitution without growth hormone (GH) replacement. GHD patients are resistant to insulin, which is a potential risk factor for cardiovascular mortality. LÄS MER

  7. 5. The Gastrin-ECL Cell Axis. Functional Aspects

    Författare :Maria Björkqvist; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; Calcium channels; CCK receptor antagonists; Misoprostol; Galanin; Somatostatin; Pancreastatin; Histamine; VIP; Gastrin; PACAP;

    Sammanfattning : The ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. LÄS MER