Sökning: "GH deficiency"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden GH deficiency.

1. 1. Metabolic Effects of Growth Hormone Replacement Therapy in Adults - with Special Reference to Insulin Sensitivity

   Författare :Mikael Segerlantz; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; Endokrinologi; sekretion; diabetologi; cortisol replacement; lipid oxidation; glucose metabolism; glucose uptake; insulin resitance; GH; insulin sensitivity; GH deficiency;

   Sammanfattning : A risk for premature atherosclerosis and increased cardiovascular mortality has been reported in adult patients suffering from growth hormone deficiency (GHD) and receiving conventional hormone substitution without growth hormone (GH) replacement. GHD patients are resistant to insulin, which is a potential risk factor for cardiovascular mortality. LÄS MER

3. 2. Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency

   Författare :Edna J L Barbosa; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone deficiency; hypopituitarism; growth hormone replacement therapy; prediction models; candidate gene approach; polymorphisms; body composition; growth hormone receptor; lipid metabolism; extracellular water; pharmacogenomics;

   Sammanfattning : The overall aim of this thesis was to study clinical and genetic factors that influence response to growth hormone replacement therapy (GHRT) in GH deficient (GHD) adults. The patients were part of a cohort of adults with hypopituitarism and severe GHD who were studied before and after 12 months of GHRT. LÄS MER

4. 3. Bone health and cardiovascular risk in hypopituitary patients on complete hormone replacement, including GH

   Författare :Helene Holmer; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; diabetologi; Endokrinologi; Craniopharyngioma; insulin tolerance test; Endocrinology; secreting systems; diabetology; cardiovascular risk; growth hormone deficiency; fracture incidence; bone mineral density; growth hormone replacement;

   Sammanfattning : Growth hormone deficiency (GHD) is associated with decreased bone mineral density (BMD). Low BMD is correlated to increased fracture risk. There are no studies on fracture risk in GHD patients on GH therapy and no studies on BMD in adults with childhood onset (CO) craniopharyngioma (CP) on GH therapy. LÄS MER

5. 4. Quality of Life in Adult Patients with Growth Hormone Deficiency : Bridging the gap between clinical evaluation and health economic assessment

   Författare :Maria Kołtowska-Häggström; Kesrtin (Chris) Bingefors; Dag Isacson; Paul Kind; Jens Sandahl Christiansen; Uppsala universitet; []
   Nyckelord :Health policy and health economics; growth hormone deficiency in adults; quality of life; cost-utility analysis; growth hormone replacement; normative data; QoL-AGHDA; Hälsopolitik och hälsoekonomi;

   Sammanfattning : The goals of this thesis are to evaluate quality of life (QoL) in adult patients with growth hormone deficiency (GHD) in relation to population normative data, to construct a preference-weighted index (utility) from a disease-specific QoL measure and to assess it in a clinical context.The study included samples from the general population and patients with GHD from four European populations: England & Wales, the Netherlands, Spain and Sweden. LÄS MER

7. 5. Effects of growth hormone on cardiovascular risk factors and atherosclerosis

   Författare :Maria Leonsson Zachrisson; Göteborgs universitet; []
   Nyckelord :growth hormone; pituitary deficiency; dietary fat; cholesterol; low density; lipoprotein; intima-media thickness; IL-6; CRP; TNF-á;

   Sammanfattning : Hypopituitary patients with growth hormone (GH) deficiency (GHD) have increasedmorbidity and mortality from cardiovascular disease (CVD). GH treatment has both beneficialand potentially negative cardiovascular effects. LÄS MER